-thalidomid
https://helix.northwestern.edu/article/thalidomide-tragedy-lessons-drug-safety-and-regulation


-tgn1412
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964774/
https://www.nejm.org/doi/full/10.1056/NEJMoa063842


-bia10-2474
https://www.researchgate.net/publication/308410862_What_failed_BIA_10-2474_Phase_I_clinical_trial_Global_speculations_and_recommendations_for_future_Phase_I_trials
https://www.sciencedirect.com/science/article/pii/S0273230019303046
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2816%2932515-6/fulltext

-rofecoxib
https://www.sukl.sk/sk/media/tlacove-spravy-2004/oznam-o-stiahnuti-liekov-vioxx-a-ceoxx-30-9-2004-?page_id=445



https://www.cochrane.org/
https://www.sciencedirect.com/science/article/pii/S0140673619332209
www.alltrials.net
www.ema.europa.eu/ema

-up-and-down designs
https://graham-wheeler.shinyapps.io/AplusB/
https://moffitt.org/media/1310/200.pdf